Leukemia Inhibitory Factor (LIF), Mouse, Recombinant Brief introduction:Leukemic suppressor factor (LIF) is a multipotent cytokine belonging to the long quadruple helix bundle cytokine superfamily. The tertiary structure of LIF is similar to interleukin-6 (IL-6), tumor suppressor M, ciliary neurotrophin, myocardial trophin-1 and other cytokines, and its functions in vivo are also redundant to a certain extent. LIF binds to the common receptor of the IL-6 subfamily (gp130) and then forms a ternary complex with its own receptor, the LIF receptor. The basic expression level of LIF in vivo is low, and its expression is induced by lipopolysaccharide, IL-1, IL-17 and other pro-inflammatory factors, and inhibited by IL-4, IL-13 and other anti-inflammatory drugs. The functions of LIF include primordial germ cell proliferation, blastocyst implantation and early pregnancy regulation, and pluripotent stem cell maintenance.Recombinant Mouse Leukemia Inhibitory factor (rmLIF) is a 180 amino acid non-glycated polypeptide chain produced by Escherichia coli with a molecular mass of 19.9kDa.Nicknames: Leukemia Inhibitory Factor (LIF), Mouse, Recombinant; CDF;  HILDA;  D-FACTOR;  Differentiation-stimulating factor;  Melanoma-derived LPL inhibitor;  MLPLI;  Emfilermin;  LIF;  DIAPhysical properties and indexes:Purity: >95%Endotoxin: <0.2 EU/μgTiter: >1 x 108units/mgExpression host: E. coliSource: MousePurification Method: purification by chromatographyCharacter: This product is white loose bodyStability: Freeze-dried powder can be stored at -20℃ for 12 months, dissolved liquid can be stored at -20℃ for 3 months, 2 weeks at 4℃, and avoid repeated freeze-thawAmino acid sequence:SPLPITPVNA TCAIRHPCHG NLMNQIKNQL AQLNGSANAL FISYYTAQGE PFPNNVEKLC APNMTDFPSF HGNGTEKTKL VELYRMVAYL SASLTNITRD QKVLNPTAVS  LQVKLNATID VMRGLLSNVL CRLCNKYRVG HVDVPPVPDH SDKEAFQRKK LGCQLLGTYK QVISVVVQAF SPLPITPVNA TCAIRHPCHG NLMNQIKNQL  AQLNGSANAL FISYYTAQGE PFPNNVEKLC APNMTDFPSF HGNGTEKTKL VELYRMVAYL SASLTNITRD QKVLNPTAVS LQVKLNATID VMRGLLSNVL CRLCNKYRVG  HVDVPPVPDH SDKEAFQRKK LGCQLLGTYK QVISVVVQAF 

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