Product Name	Rabbit Anti-NGEF Polyclonal Antibody
Cat No.	SLA0322
Chinese Name	磷酸化神经细胞鸟苷酸置换因子Ephexin1抗体
Alias	ARHGEF27; EPHEXIN; Tims2; Besh3; ephexin-1; NGEF_HUMAN; NGEF; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; NGEF_MOUSE; NGEF_RAT; ephexin1; NGEF | Ephexin-1 (phospho-Y87); p-Ephexin-1; phospho-Ephexin-1; p-NGEF; NGEF | Ephexin-1 (phospho-Tyr87);
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Applications	WB (1:300-5000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated Synthesised phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr87
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	82 kDa
Subcellular Location	Cytoplasm
Gene ID	25791
Swiss-Prot	Q8N5V2
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.