Product Name	ERG Mouse mAb
Cat No.	SLM-51816M
Chinese Name
Alias	LMPHM14; erg-3; p55; D030036I24Rik; ERG_HUMAN; ERG; Transforming protein ERG; ERG_MOUSE; ETS transcription factor ERG; v-ets avian erythroblastosis virus E26 oncogene related; v-ets avian erythroblastosis virus E26 oncogene homolog; transcriptional regulator ERG (transforming protein ERG); v-ets erythroblastosis virus E26 oncogene like; TMPRSS2-ERG prostate cancer specific; ETS-related gene
Host Species	Mouse
Isotype	IgG3/Kappa
Clonality	Monoclonal
Clone No.	2E11
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human ERG
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	55 kDa
Observed MW.
Subcellular Location	N/A
Gene ID
Swiss-Prot	P11308
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development , cell proliferation , differentiation , angiogenesis , inflammation , and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium , inducing vascular cell remodeling. It also regulates hematopoesis , and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations , resulting in different fusion gene products , such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer , EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported , but the full-length nature of many of these variants has not been determined. [provided by RefSeq , Apr 2014]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.