Product Name	Recombinant Rabbit Anti-ApoB Monoclonal Antibody
Cat No.	SLA0916M
Chinese Name	载脂蛋白B重组兔单抗
Alias	FCHL2; FLDB; LDLCQ4; apoB-100; apoB-48; Apo B-100; APOB_HUMAN; APOB; APOB_MOUSE; apolipoprotein B; apolipoprotein B (including Ag(x) antigen)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant mouse Apolipoprotein B protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	516 kDa
Subcellular Location	Cytoplasm
Gene ID	238055
Swiss-Prot	E9Q414
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.