Product Name	Rabbit Anti-H3C1 Polyclonal Antibody
Cat No.	SLA0293
Chinese Name	三甲基化组蛋白H3a抗体
Alias	H3C1 | Histone H3 (tri-methyl-K27); H3K27me3; me3-Histone H3; tri-methyl-Histone H3; me3-H3; H3C1 | Histone H3 (tri-methyl-Lys27); H3/A; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; HIST1H3A; H3/b; H3C1; H3FB; HIST1H3D; H3.1; H3/c; H3FC;
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Applications	WB () IF () ELISA () dot-blot () ChIP-seq () Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthesised methylpeptide derived from human Histone H3 around the methylation site of Tri Methyl K27
Purification	affinity purified by Protein A
Concentration	1.45ug/ul
Predicted MW.	15 kDa
Subcellular Location	Nucleus
Swiss-Prot	Q71DI3
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.