Product Name	Recombinant Rabbit Anti-ABCG2 Monoclonal Antibody
Cat No.	SLA1027M
Chinese Name	三磷酸腺苷结合转运蛋白G超家族成员2重组兔单抗
Alias	ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1; ABCG2; ABCG2_HUMAN; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; 7.6.2.2; ABCG2_MOUSE; Breast cancer resistance protein 1 homolog; ABCG2_PIG; Brain multidrug resistance protein; ABCG2_RAT; ATP binding cassette subfamily G member 2 (JR blood group); ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); ATP binding cassette subfamily G member 2 (Junior blood group);
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	5F8
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human ABCG2
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	72 kDa
Gene ID	9429
Swiss-Prot	Q9UNQ0
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.