Product Name	Recombinant Rabbit Anti-NOTCH3 Monoclonal Antibody
Cat No.	SLA3561M
Alias	CADASIL; CADASIL1; CARASIL1; CASIL; FPLD1; IMF2; LMNS; N3; hpbk; NOTC3_HUMAN; NOTCH3; Notch 3; NOTC3_MOUSE; NOTC3_RAT; notch receptor 3; Notch (Drosophila) homolog 3; Notch homolog 3 (Drosophila); NOTCH3 (Cleaved-Asp1628); Neurogenic locus notch homolog protein 3; [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	11A9
React Species	Human,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) IP (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	4854
Swiss-Prot	Q9UM47
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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