Product Name	Recombinant Rabbit Anti-FBXW7 Monoclonal Antibody
Cat No.	SLA3498M
Alias	AGO; CDC4; DEDHIL; FBW6; FBW7; FBX30; FBXO30; FBXW6; SEL-10; SEL10; hAgo; hCdc4; 1110001A17Rik; Fbwd6; FBXW7_HUMAN; FBXW7; Archipelago homolog (hAgo); F-box and WD-40 domain-containing protein 7; F-box protein FBX30; FBXW7_MOUSE; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box and WD repeat domain containing 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; archipelago homolog (Drosophila); F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	10E3
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:50-200) IHC-F (1:50-200) IF (1:50-200) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Gene ID	55294
Swiss-Prot	Q969H0
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Fbw7 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class; in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5' termini.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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