Product Name	Rabbit Anti-PYCARD Polyclonal Antibody
Cat No.	SLA0321
Chinese Name	磷酸化凋亡相关斑点样蛋白ASC抗体
Alias	ASC; CARD5; TMS; TMS-1; TMS1; ASC_HUMAN; PYCARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; PYD and CARD domain containing; apoptosis-associated speck-like; apoptosis-associated speck-like protein containing a CARD; Caspase, PYCARD, AIM, ASC, CARD5, TMS1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Applications	WB (1:300-5000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Asc (Tyr144) phospho-peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-144 in mouse Asc. This peptide sequence is highly conserved in human and rat Asc.
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	21 kDa
Subcellular Location	Nucleus
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Tissue specificity: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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