Product Name	Recombinant Rabbit Anti-MIB1 Monoclonal Antibody
Cat No.	SLA1919M
Chinese Name	E3泛素蛋白连接酶MIB1重组兔单抗
Alias	DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6; E430019M12Rik; mindbomb; MIB1_HUMAN; MIB1; DAPK-interacting protein 1 (DIP-1); Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2; 2.3.2.27; KIAA1323; MIB1_MOUSE; MIB E3 ubiquitin protein ligase 1; mindbomb homolog 1 (Drosophila); DAPK-interacting protein 1
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
React Species	Human,Mouse
Applications	WB (1:500-2000) ICC/IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human MIB1
Purification	affinity purified by Protein A
Predicted MW.	110 kDa
Observed MW.	110 kDa
Subcellular Location	Cytoplasm
Gene ID	57534
Swiss-Prot	Q86YT6
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.