Product Name	Recombinant Rabbit Anti-EGLN1 Monoclonal Antibody
Cat No.	SLA1638M
Chinese Name	脯氨酸羟化酶2重组兔单抗
Alias	C1orf12; ECYT3; HALAH; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM20; ZMYND6; EGLN1_HUMAN; EGLN1; Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2 | HIF-prolyl hydroxylase 2 | HPH-2); Prolyl hydroxylase domain-containing protein 2 (PHD2); SM-20; 1.14.11.29; egl-9 family hypoxia inducible factor 1; EGL nine (C.elegans) homolog 1; egl nine homolog 1 (C. elegans); egl-9 family hypoxia-inducible factor 1; HIF prolyl hydroxylase 2
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
React Species	Human
Applications	WB (1:500-2000) IP (1:20-50) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human PHD2
Purification	affinity purified by Protein A
Predicted MW.	46 kDa
Observed MW.	46 kDa
Gene ID	54583
Swiss-Prot	Q9GZT9
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.