Product Name	Recombinant Rabbit Anti-APOB Monoclonal Antibody
Cat No.	SLA0491M
Chinese Name	载脂蛋白B单克隆抗体
Alias	FCHL2; FLDB; LDLCQ4; apoB-100; apoB-48; Apo B-100; APOB_HUMAN; APOB; APOB_MOUSE; apolipoprotein B; apolipoprotein B (including Ag(x) antigen)
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
Clone No.	5F9
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IF (1:50-100) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	515 kDa
Subcellular Location	Cytoplasm
Storage	0.01M PBS (pH7.4). Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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