Product Name	Recombinant Rabbit Anti-RIPK1 Monoclonal Antibody
Cat No.	SLA1081M
Chinese Name	磷酸化丝氨酸苏氨酸激酶1受体相互作用蛋白单克隆抗体
Alias	AIEFL; IMD57; RIP; RIP-1; RIP1; D330015H01Rik; Rinp; RIPK1_HUMAN; RIPK1; Cell death protein RIP; Receptor-interacting protein 1 (RIP-1); 2.7.11.1; RIPK1_MOUSE; receptor interacting serine/threonine kinase 1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting protein kinase 1; RIPK1 (phospho-S161); p-RIPK1; phospho-RIPK1; RIPK1 (phospho-Ser161)
Host Species	Mouse
Isotype	IgG1, k
Clonality	Monoclonal
React Species	Human
Applications	WB (1:500-1000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated Synthesised phosphopeptide derived from human RIPK1 around the phosphorylation site of Ser161
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	74 kDa
Observed MW.	85 kDa
Gene ID	8737
Swiss-Prot	Q13546
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.