Product Name	Recombinant Rabbit Anti-ADGRE1 Monoclonal Antibody
Cat No.	SLA0386M
Chinese Name	小鼠F4/80单克隆抗体
Alias	AGRE1_HUMAN; ADGRE1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; EMR1; TM7LN3; AGRE1_MOUSE; Cell surface glycoprotein F4/80; Gpf480; adhesion G protein-coupled receptor E1; egf-like module containing, mucin-like, hormone receptor-like sequence 1; egf-like module containing, mucin-like, hormone receptor-like 1
Host Species	Rat
Isotype	Rat IgG2b, k
Clonality	Monoclonal
Clone No.	5G1
Applications	Flow-Cyt () Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Purification	affinity purified by Protein G
Predicted MW.	95 kDa
Observed MW.	160 kDa
Subcellular Location	Membrane
Storage	0.01M PBS (pH7.4). Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.