Product Name	Recombinant Rabbit Anti-AR Monoclonal Antibody
Cat No.	SLA0470M
Chinese Name	雄激素受体（AR）单克隆抗体
Alias	AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; Andr; ANDR_HUMAN; AR; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; ANDR_MOUSE; ANDR_RAT; androgen receptor; spinal and bulbar muscular atrophy; testicular feminization; Kennedy disease
Host Species	Mouse
Isotype	IgG2b/Kappa
Clonality	Monoclonal
Clone No.	8B7
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-200) IHC-F (1:100-200) IF (1:100-200) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Androgen Receptor
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	99 kDa
Subcellular Location	Nucleus
Gene ID	367
Swiss-Prot	P10275
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.