Product Name	Recombinant Rabbit Anti-CDKN1B Monoclonal Antibody
Cat No.	SLA0704M
Chinese Name	周期素依赖激酶抑制剂/P27单克隆抗体
Alias	CDKN4; KIP1; MEN1B; MEN4; P27KIP1; p27; Cdki1b; CDN1B_HUMAN; CDKN1B; Cyclin-dependent kinase inhibitor p27; CDN1B_MOUSE; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
Clone No.	10B7
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human CDKN1B
Purification	affinity purified by Protein G
Concentration	1mg/1ml
Predicted MW.	22 kDa
Subcellular Location	Nucleus
Gene ID	1027
Swiss-Prot	P46527
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.