Product Name	Rabbit Anti-DACT3 Polyclonal Antibody
Cat No.	SLA0011
Chinese Name	Dapper3蛋白抗体
Alias	DAPPER3; RRR1; EG666671; naa-3; RGD1563892; DACT3_HUMAN; DACT3; Antagonist of beta-catenin Dapper homolog 3; Arginine-rich region 1 protein; Dapper antagonist of catenin 3; DACT3_MOUSE; dishevelled binding antagonist of beta catenin 3; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ICC/IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human DACT3
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	65 kDa
Gene ID	147906
Swiss-Prot	Q96B18
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Dapper3 is a 629 amino acid protein and mammalian homolog of the Xenopus laevis protein dapper. As a member of the dapper family, Dapper3 plays a role in postnatal brain development and contains a C-terminal PDZ-binding motif that facilitates interaction with the PDZ domains of DSH (Dishevelled) family proteins. As the predominant dapper family member found in adult brain, Dapper 3 localizes to hippocampus, Purkinje cell layer and every layer of the dorsal forebrain and cerebral cortex and is also found in the developing murine central nervous system. Dapper3 is also expressed in uterus, ventral somites, branchial arch mesenchyme, aortic sac, aortic arches, limb bud mesenchyme and craniofacical mesenchyme. Mapping to human chromosome 19q13.32, Dapper3 has been identified as a negative regulator of Wnt/beta-catenin signaling in colorectal cancer.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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