Product Name	Recombinant Rabbit Anti-NTRK1 Monoclonal Antibody
Cat No.	SLA0995M
Chinese Name	酪氨酸激酶受体A重组兔单抗
Alias	MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; Tkr; NTRK1_HUMAN; NTRK1; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A (Trk-A); gp140trk; 2.7.10.1; NTRK1_MOUSE; NTRK1_RAT; Slow nerve growth factor receptor; p140-TrkA (Trk-A); neurotrophic receptor tyrosine kinase 1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; tropomyosin receptor kinase A
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	2G12
React Species	Mouse,Rat
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human TrkA
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	84 kDa
Observed MW.	140 kDa
Gene ID	4914
Swiss-Prot	P04629
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.