Product Name	Recombinant Rabbit Anti-OLIG1 Monoclonal Antibody
Cat No.	SLA1114M
Chinese Name	少突胶质细胞转录因子1重组兔单抗
Alias	BHLHB6; BHLHE21; Olg-1; Oligo1; Olg1; OLIG1_HUMAN; OLIG1; Class B basic helix-loop-helix protein 6 (bHLHb6); Class E basic helix-loop-helix protein 21 (bHLHe21); OLIG1_MOUSE; Oligodendrocyte-specific bHLH transcription factor 1; OLIG1_RAT; Olg-1 bHLH protein; oligodendrocyte transcription factor 1; oligodendrocyte lineage transcription factor 1; basic domain, helix-loop-helix protein, class B, 6
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	2B3
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Oligo1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	28 kDa
Observed MW.	34 kDa
Subcellular Location	Nucleus
Gene ID	116448
Swiss-Prot	Q8TAK6
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.