Product Name	Recombinant Rabbit Anti-CCNH Monoclonal Antibody
Cat No.	SLA1552M
Chinese Name	周期素H重组兔单抗
Alias	CAK; CycH; p34; p37; 6330408H09Rik; CCNH_HUMAN; CCNH; MO15-associated protein; CCNH_MOUSE; cyclin H; CDK-activating kinase complex subunit; cyclin-dependent kinase-activating kinase complex subunit; CAK complex subunit
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	5B5
React Species	Human
Applications	WB (1:500-2000) Flow-Cyt (1:50-100) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human Cyclin H
Purification	affinity purified by Protein A
Predicted MW.	38 kDa
Observed MW.	38 kDa
Subcellular Location	Nucleus
Gene ID	902
Swiss-Prot	P51946
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.