Product Name	Recombinant Rabbit Anti-CD3E Monoclonal Antibody
Cat No.	SLA1074M
Chinese Name	CD3E重组兔单抗
Alias	CD3epsilon; IMD18; T3E; TCRE; CD3; CD3E_HUMAN; CD3E; T-cell surface antigen T3/Leu-4 epsilon chain; CD3E_MOUSE; CD3 epsilon subunit of T-cell receptor complex; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3e molecule; T-cell surface glycoprotein CD3 epsilon chain
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	12A3
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human CD3 epsilon
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	20 kDa
Subcellular Location	Membrane
Gene ID	916
Swiss-Prot	P07766
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.