Product Name	Rabbit Anti-AURKA Polyclonal Antibody
Cat No.	SLA0120
Chinese Name	磷酸化有丝分裂激酶A抗体
Alias	AIK; ARK1; AURA; BTAK; PPP1R47; STK15; STK6; STK7; AIRK1; ARK-1; Aurora-A; Ayk1; IAK; IAK1; AURKA_HUMAN; AURKA; Aurora 2; Aurora/IPL1-related kinase 1 (ARK-1 | Aurora-related kinase 1); Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A; 2.7.11.1; AURKA_MOUSE; aurora kinase A; serine/threonine kinase 15; serine/threonine kinase 6; protein phosphatase 1, regulatory subunit 47; Aurora-A kinase; AURKA | Aurora A (phospho-T288); p-Aurora A; phospho-Aurora A; p-AURKA; AURKA | Aurora A (phospho-Thr288)
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated Synthesised phosphopeptide derived from human Aurora A around the phosphorylation site of Thr288
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	48 kDa
Observed MW.	48 kDa
Subcellular Location	Nucleus
Gene ID	6790
Swiss-Prot	O14965
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localizes to the inner centromere region from prophase to anaphase. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.