Product Name	Recombinant Rabbit Anti-TMEM43 Monoclonal Antibody
Cat No.	SLA2637M
Chinese Name	跨膜蛋白43重组兔单抗
Alias	ARVC5; ARVD5; AUNA3; EDMD7; AUNA2; LUMA; 1200015A22Rik; TMM43_HUMAN; TMEM43; Protein LUMA; TMM43_MOUSE; TMM43_RAT; transmembrane protein 43; arrhythmogenic right ventricular dysplasia 5
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	12G8
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human TMEM43
Purification	affinity purified by Protein A
Predicted MW.	45 kDa
Observed MW.	43 kDa
Gene ID	79188
Swiss-Prot	Q9BTV4
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with TMEM43 monoclonal antibody, unconjugated (SLA2637M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Mouse Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Rat Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 4. Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 5. Paraformaldehyde-fixed, paraffin embedded Rat Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 6. Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 7. Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TMEM43 Monoclonal Antibody, Unconjugated (SLA2637M) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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