Product Name	Madcam1 | MAdCAM-1 Rabbit pAb
Cat No.	SL42393R
Chinese Name	粘膜细胞粘附分子1抗体
Alias	MACAM1; MAdCAM-1; MADCA_HUMAN; MADCAM1; hMAdCAM-1; MADCA_MOUSE; mMAdCAM-1; MADCA_RAT; rMAdCAM-1; mucosal vascular addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Mouse,Rat
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant mouse MADCAM1 protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	38 kDa
Observed MW.	42 kDa
Subcellular Location	Membrane
Gene ID	17123
Swiss-Prot	Q61826
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin Alpha 4/Beta 7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with MADCAM1 polyclonal antibody, unconjugated (SL42393R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.