Product Name	Rabbit Anti-SLC51B Polyclonal Antibody
Cat No.	SLA0168
Chinese Name	有机溶质转运蛋白OSTβ抗体
Alias	OSTB_HUMAN; SLC51B; OST-beta; Solute carrier family 51 subunit beta; OSTB; OSTBETA; PBAM2; SLC51A1BP; SLC51 subunit beta; organic solute transporter beta subunit; SLC51A1 binding protein
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human OST-beta protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	14 kDa
Observed MW.	35 kDa
Subcellular Location	Membrane
Gene ID	123264
Swiss-Prot	Q86UW2
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 20 ng rhOST-beta-GST protein (SL42194P) per lane probed with OST-beta polyclonal antibody respectively, unconjugated (SLA0168) at 1:1000 dilution and 4°C overnight incubation. Followed by corresponding conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.