Product Name	Rabbit Anti-GABRA1 Polyclonal Antibody
Cat No.	SLA0177
Chinese Name	G1氨基丁酸A型受体α1抗体
Alias	DEE19; ECA4; EIEE19; EJM; EJM5; GABAA-alpha1; GABAAR-alpha1; Gabra-1; GBRA1_CHICK; GABRA1; GABA(A) receptor subunit alpha-1 (GABAAR subunit alpha-1); GBRA1_BOVIN; GBRA1_HUMAN; GBRA1_MOUSE; GBRA1_RAT; gamma-aminobutyric acid type A receptor subunit alpha1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; GABA(A) receptor, alpha 1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human GABRA1 protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	52 kDa
Observed MW.	27 kDa
Subcellular Location	Membrane
Gene ID	2554
Swiss-Prot	P14867
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R©1-3, GABAA R∂, GABAA R gamma, GABAA R delta 1 and GABAA R delta 2. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Recombinant human GABRA1 protein, N-His(SL42256P) Primary: Anti-GABRA1 (SLA0177) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 27 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.