Product Name	SIGLEC15 | CD33L3 Mouse mAb
Cat No.	SLM-43036M
Chinese Name	唾液酸结合性免疫球蛋白样凝集素15单克隆抗体
Alias	CD33L3; HsT1361; SIGLEC-15; SIG15_HUMAN; SIGLEC15; CD33 antigen-like 3; sialic acid binding Ig like lectin 15; CD33 molecule-like 3; sialic acid binding Ig-like lectin 15
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
Clone No.	10E10
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human SIGLEC15 protein
Purification	affinity purified by Protein A
Predicted MW.	34 kDa
Observed MW.	36 kDa
Subcellular Location	Membrane
Gene ID	284266
Swiss-Prot	Q6ZMC9
Storage	Size : 50ul/100ul/200ul 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Size : 200ug (PBS only) 0.01M PBS (pH7.4). Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated Siglecs or sialoadhesins, recognize sialylated ligands and play a key role in mediating sialic-acid dependent binding to cells. Siglec-15 (sialic acid binding Ig-like lectin 15), also known as CD33L3, is a 328 amino acid single-pass type I membrane protein that contains one Ig-like C2-type domain and one Ig-like V-type domain. Expressed in dendritic and macrophage cells, Sinlec-15 interacts with DAP10 and DAP12 and binds to sialylated glycoproteins. The gene encoding Siglec-15 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Human HepG2 cell lysates Lane 2: Human U87MG cell lysates Primary: Anti-SIGLEC15 (SLM-43036M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 34 kDa Observed band size: 36 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.