Product Name	Rabbit Anti-HSPG2 Polyclonal Antibody
Cat No.	SLA0171
Chinese Name	硫酸乙酰肝素蛋白多糖2抗体
Alias	HSPG; PLC; PRCAN; SJA; SJS; SJS1; Pcn; per; PGBM_HUMAN; HSPG2; Perlecan (PLC); PGBM_MOUSE; heparan sulfate proteoglycan 2; Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia); perlecan proteoglycan; endorepellin
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human HSPG2 protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	469 kDa
Observed MW.	27 kDa
Subcellular Location	Membrane
Gene ID	3339
Swiss-Prot	P98160
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans(heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Recombinant human HSPG2 protein, N-His(SL42231P) Primary: Anti-HSPG2 (SLA0171) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 469 kDa Observed band size: 27 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.