Product Name	Rabbit Anti-TNFRSF11A Polyclonal Antibody
Cat No.	SLA0245
Chinese Name	核转录因子NF-κB受体抗体(核因子kB受体活化因子)
Alias	CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCE-R; TRANCER; TNR11_HUMAN; TNFRSF11A; Osteoclast differentiation factor receptor (ODFR); Receptor activator of NF-KB; TNF receptor superfamily member 11a; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; Paget disease of bone 2; loss of heterozygosity, 18, chromosomal region 1; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; osteoclast differentiation factor receptor; receptor activator of nuclear factor kappa B; familial expansile osteolysis; TRANCE receptor
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human RANK protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	66 kDa
Subcellular Location	Membrane
Gene ID	8792
Swiss-Prot	Q9Y6Q6
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Human Abdominal skin; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with RANK Polyclonal Antibody, Unconjugated (SLA0245) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.