Product Name	Rabbit Anti-GDF15 Polyclonal Antibody
Cat No.	SLA0039
Chinese Name	生长分化因子15/巨嗜细胞抑制因子1抗体
Alias	GDF-15; HG; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB; SBF; GDF15_HUMAN; GDF15; Macrophage inhibitory cytokine 1 (MIC-1); NSAID-activated gene 1 protein (NAG-1); NSAID-regulated gene 1 protein (NRG-1); Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; GDF15_MOUSE; GDF15_RAT; growth differentiation factor 15; non-steroidal anti-inflammatory drug-activated gene-1; macrophage inhibitory cytokine-1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human GDF15
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	12.5/34 kDa
Observed MW.	34 kDa
Subcellular Location	Secreted
Gene ID	9518
Swiss-Prot	Q99988
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with GDF15 polyclonal antibody, unconjugated (SLA0039) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.