Product Name	ATRX Rabbit pAb
Cat No.	SL22693R
Chinese Name	ATP依赖性解旋酶ATRX抗体
Alias	JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX; 4833408C14Rik; ATR2; DXHXS6677E; HP1-BP38; Hp1bp2; Hp1bp38; MRXS3; ATRX_HUMAN; ATRX; ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein (XNP); 3.6.4.12; ATRX_MOUSE; HP1 alpha-interacting protein; HP1-BP38 protein; Heterochromatin protein 2; X-linked nuclear protein; ATRX_RAT; pABP-2; ATRX chromatin remodeler; alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae) homolog); Juberg-Marsidi syndrome; mental retardation, X-linked 52; alpha thalassemia/mental retardation syndrome X-linked; RAD54 homolog (S. cerevisiae)
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	ICC/IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human ATRX
Concentration	1mg/ml
Predicted MW.	283 kDa
Gene ID	546
Swiss-Prot	P46100
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. SH-SY5Y cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (ATRX) polyclonal Antibody, Unconjugated (SL22693R) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.