Product Name	Recombinant Rabbit Anti-CYP7A1 Monoclonal Antibody
Cat No.	SLA0561M
Chinese Name	细胞色素P450 7A1抗体/胆固醇7a羟化酶单克隆抗体
Alias	CP7A; CYP7; CYPVII; CYPVIIc; CHAP; CYP7S1; CP7A1_HUMAN; CYP7A1; 24-hydroxycholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; CP7A1_MOUSE; CP7A1_RAT; cytochrome P450 family 7 subfamily A member 1; cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase), polypeptide 1; cytochrome P450, family 7, subfamily A, polypeptide 1; cholesterol 7 alpha-monooxygenase; cholesterol 7α-hydroxylase
Host Species	Mouse
Isotype	IgG
Clonality	Monoclonal
Clone No.	3E11
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human CYP7A1 protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	55 kDa
Subcellular Location	Membrane
Gene ID	1581
Swiss-Prot	P22680
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CYP7A1 Monoclonal Antibody, Unconjugated (SLA0561M) at 1:200 overnight at 4°C, followed by conjugation to the SL40296G-HRP and DAB (C-0010) staining.

Figure 2. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CYP7A1 Monoclonal Antibody, Unconjugated (SLA0561M) at 1:200 overnight at 4°C, followed by conjugation to the SL40296G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

Ordering & shipping

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