Product Name	Rabbit Anti-MORC2 Polyclonal Antibody
Cat No.	SLA0072
Chinese Name	ZCWCC1抗体
Alias	CMT2Z; DIGFAN; ZCW3; ZCWCC1; MORC2_HUMAN; MORC2; MORC family CW-type zinc finger protein 2; Zinc finger CW-type coiled-coil domain protein 1; 3.6.1.-; KIAA0852; MORC family CW-type zinc finger 2; zinc finger, CW-type with coiled-coil domain 1; zinc finger, CW type with coiled-coil domain 1
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:400-800) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human ZCWCC1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	118 kDa
Observed MW.	120 kDa
Subcellular Location	Nucleus
Gene ID	22880
Swiss-Prot	Q9Y6X9
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The CW domain is a structural module found in many vertebrate, parasitic and plant proteins. It consists of a mononuclear four-cysteine zinc-finger domain that plays a role in DNA binding, chromatin methylation and early embryonic development. ZCWCC1 (zinc finger CW-type coiled-coil domain protein 1), also known as MORC2 (MORC family CW-type zinc finger protein 2) or ZCW3, is a 1,032 amino acid protein that contains one CW-type zinc finger domain. ZCWCC1 is located on chromosome 22 and is ubiquitously expressed with highest expression in pancreas, smooth muscle and testis. Expression of ZCWCC1 is upregulated in hypoxia, a pathological condition characterized by an inadequate supply of oxygen in the blood.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Rat Testis tissue lysates Lane 3: Human MCF-7 cell lysates Primary: Anti-ZCWCC1 (SLA0072) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 118 kDa Observed band size: 120 kDa

Figure 2. Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (ZCWCC1) Polyclonal Antibody, Unconjugated (SLA0072) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.