Product Name	Anti-ZWINT/AP
Chinese Name	碱性磷酸酶（AP）标记的着丝粒ZW10相互作用蛋白1抗体
Alias	HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN.
Research Area	Cell biology Cyclin Cell differentiation Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
Applications	WB=1000-10000,IHC-P=1:100-500,IHC-F=1:100-500,ELISA=1:500-5000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	31 kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from huamn ZWINT
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis. Function: Part of the MIS12 complex, which is required forkinetochore formation and spindle checkpoint activity. Required totarget ZW10 to the kinetochore at prometaphase. Subunit: Interacts with ZW10 and MIS12. Interacts with the NDC80subunit of the NDC80 complex specifically during mitosis. Alsointeracts with CASC5, CETN3, DSN1 and PMF1. Subcellular Location: Nucleus. Chromosome, centromere,kinetochore. Note=Localizes to kinetochores from late prophase toanaphase. Database links: UniProtKB/Swiss-Prot: O95229.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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