Product Name	Anti-MAP3K2/AP
Chinese Name	碱性磷酸酶（AP）标记的丝裂原活化蛋白激酶激酶2抗体
Alias	M3K2_HUMAN; Map3k2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; MEKK2b; Mitogen activated protein kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2.
Research Area	Signal transduction transcriptional regulatory factor Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Horse,Rabbit)
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	68kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MAP3K2/MEKK2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. Sequence similarities; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 OPR domain. Contains 1 protein kinase domain. Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. Subunit: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity. Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Autophosphorylated (By similarity). Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 OPR domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 10746 Human Entrez Gene: 26405 Mouse Entrez Gene: 171492 Rat Omim: 609487 Human SwissProt: Q9Y2U5 Human SwissProt: Q61083 Mouse Unigene: 145605 Human Unigene: 211762 Mouse Unigene: 213212 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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