Product Name	Anti-phospholipasae C/AP
Chinese Name	碱性磷酸酶（AP）标记的产气荚膜梭菌(魏氏梭菌)磷脂酶C抗体
Alias	PLC.
Research Area	immunology Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted:Clostridium perfringens)
Applications	WB=1000-10000,IHC-P=1:100-500,IHC-F=1:100-500,ELISA=1:500-5000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	43kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	Recombinded phospholipasae C full length protein
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     A型产气荚膜梭菌病,又称魏氏梭菌性肠炎,是由A型产气英膜梭菌产生的外毒素引起的肠毒血症,产气荚膜梭菌广泛分布于自然界及人和动物消化道内 ,能引起人气性坏疽、食物中毒和多种动物的坏死性肠炎及肠毒血症等 ,产气荚膜梭菌是近年来我国家畜猝死症的主要病原。产气荚膜梭菌至少能产生15种外毒素及侵袭性酶类 ,具有较强的致病力是以腹泻为特征的的一种急性致死性传染病,其发病率、死亡率均高, 对畜牧业的危害极大,造成巨大的经济损失。     在各种毒素和酶中，以α毒素最为重要，α毒素是一种卵磷脂酶，能分解卵磷脂，人和动物的The cell membrane是磷脂和蛋白质的复合物，可被卵磷脂酶所破坏，故α毒素能损伤多种细胞的The cell membrane，引起溶血、组织坏死，vascular endothelial cell损伤，使血管通透性增高，造成水肿。     A型产气荚膜梭菌也是引起人的食物中毒和气肿疽的主要病原体，亦可引起动物的坏死性肠炎和肠毒血症,产气荚膜梭菌是继沙门氏菌、葡萄球菌后引起食物中毒的又一重要的病原菌。由于它存在广泛，因而传播也比较容易。其中部分A型产气荚膜梭菌还产生一种在生物医学上具有重要意义的毒素，即肠毒素（CPE），该毒素致病性很强，并可引起人的食物中毒,CPE阳性A型产气荚膜梭菌引起的食物中毒的病例，仅次于沙门氏菌和葡萄球菌引起的食物中毒病例，约占食物中毒病例总数的4-10%.     产气荚膜梭菌分为A、B、C、D、E、F六个毒素型。其中A、C、F对人致病，但A型是毒性最强、最常见的一种，为常见的致病菌。A 引起气性坏疽和胃肠炎型食物中毒；C型能引起坏死性肠炎。

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