Product Name	Anti-ZBTB4/AP
Chinese Name	碱性磷酸酶（AP）标记的Zinc finger protein903抗体
Alias	KAISO-L1; KAISO-like zinc finger protein 1; KIAA1538; ZBTB4; ZBTB4_HUMAN; Zinc finger and BTB domain containing 4; Zinc finger and BTB domain-containing protein 4; ZNF903.
Research Area	Cell biology transcriptional regulatory factor Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
Applications	WB=1000-10000,IHC-P=1:100-500,IHC-F=1:100-500,ELISA=1:500-5000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	105kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZBTB4/ZNF903
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZBTB4 (zinc finger and BTB domain containing 4), also known as KAISO-L1 (KAISO-like zinc finger protein 1), is a 1,013 amino acid nuclear protein that is involved in transcriptional regulation. ZBTB4 contains one BTB (POZ) domain, six C2H2-type zinc fingers and is phosphorylated and downregulated by HIPK2. The gene encoding ZBTB4 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Function: May be involved in transcriptional regulation. Subunit: Interacts with HIPK2. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage. Similarity: Contains 1 BTB (POZ) domain. Contains 6 C2H2-type zinc fingers. Database links: Entrez Gene: 57659 Human Entrez Gene: 75580 Mouse Entrez Gene: 287441 Rat Omim: 612308 Human SwissProt: Q9P1Z0 Human Unigene: 35096 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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