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Rabbit Anti-TRAFD1/AP Conjugated antibody
Rabbit Anti-TRAFD1/AP Conjugated antibody
FLN29; FLN29 gene product; Protein FLN29; TRAD1_HUMAN; TRAF type zinc finger domain containing 1; TRAF type zinc finger domain containing protein 1; TRAF-type zinc finger domain-containing protein 1; TRAFD 1; TRAFD1.
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Regular members: $476.8
  • NO.:SL16564R-AP
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted:Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep)
    Applications:WB,IHC-P,IHC-F,ELISA
    concentration:1mg/ml
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Details

Product Name Anti-TRAFD1/AP
Chinese Name 碱性磷酸酶(AP)标记的TRAFD1蛋白抗体
Alias FLN29; FLN29 gene product; Protein FLN29; TRAD1_HUMAN; TRAF type zinc finger domain containing 1; TRAF type zinc finger domain containing protein 1; TRAF-type zinc finger domain-containing protein 1; TRAFD 1; TRAFD1.
Research Area immunology Signal transduction
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted:Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep)
Applications WB=1000-10000,IHC-P=1:100-500,IHC-F=1:100-500,ELISA=1:500-5000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 65kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human TRAFD1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

Function:
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.

Similarity:
Contains 1 TRAF-type zinc finger.

Database links:

Entrez Gene: 10906 Human

Entrez Gene: 114635 Rat

Omim: 613197 Human

SwissProt: O14545 Human

SwissProt: Q99MM4 Rat

Unigene: 5148 Human

Unigene: 16272 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Partial purchase records(bought amounts latest3)

UsernameQuantitybought time
Fi***12024-09-09
Pa***22024-06-18
Fe***12023-05-21
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