Product Name	Anti-HRH4/GPCR105/PE
Chinese Name	PE标记的组织胺H4受体抗体
Alias	GPCR105; GPRv53; H4 antibody H4R; HH4R; Histamine H4 receptor; AXOR35; BG26; G protein coupled receptor 105; HRH4_HUMAN; SP9144.
Research Area	Tumour immunology Signal transduction Apoptosis transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human
Applications	IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	44kDa
Cellular localization	The cell membrane
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HRH4/GPCR105
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 1M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 59340 Human Omim: 606792 Human SwissProt: Q9H3N8 Human Unigene: 287388 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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