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Product Name Anti-PNPLA8/RBITC Chinese Name 罗丹明(RBITC)标记的磷脂酶patatin样域包含蛋白8抗体 Alias Calcium-independent phospholipase A2-gamma; Intracellular membrane associated calcium independent phospholipase A2 gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; IPLA2 2; iPLA2 gamma; IPLA2(GAMMA); iPLA2-2; iPLA2-gamma; IPLA22; IPLA2G; Patatin like phospholipase domain containing protein 8; Patatin-like phospholipase domain-containing protein 8; PLPL8_HUMAN; PNPLA-gamma; PNPLA8. Research Area Tumour Cardiovascular Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 88kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PNPLA8 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function:
Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasm > perinuclear region.
Tissue Specificity:
Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
Similarity:
Contains 1 patatin domain.
Database links:Entrez Gene: 50640 Human
Entrez Gene: 67452 Mouse
Omim: 612123 Human
SwissProt: Q9NP80 Human
SwissProt: Q8K1N1 Mouse
Unigene: 617340 Human
Unigene: 732217 Human
Unigene: 54126 Mouse
Unigene: 23073 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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