Product Name	phospho-heterochromatin protein 1 (pTyr24)
Chinese Name	磷酸化异染色质蛋白1抗体（果蝇）
Alias	heterochromatin protein 1 (phospho Tyr24); heterochromatin protein 1 (phospho Y24); Antigen p25; Cbx 5; Cbx5; Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog; HP1A; HP1Hs alpha; HP1Hs-alpha.
literatures	Specific References (1) | SL0928R has been referenced in 1 publications. [IF=3.057] Terzuoli et al. Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation. (2014) PLoS.On. 9:e84358 WB ; Human. PubMed:24392129
Product Type	Phosphorylated anti
Research Area	immunology Chromatin and nuclear signals Insect
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Fruit Fly, )
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr24: EE(p-Y)AV
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. SWISS: P05205 Gene ID: N/A Database links: GenBank: ACI96782.1 异染色质蛋白1（Heterochromatin protein 1 (HP1)）一般认为是异染色质的维持者，异染色质是转录沉默的固缩DNA，常常与中心粒等区域有关。这种固缩的DNA被认为是转录因子无法接近的，但近期的Science上发表的两篇报道对这个观点提出了挑战。 这个新的研究提出HP1可能是异染色质活性调控的重要因子，在细胞生理活动中具有的重要功能。

Cartpieces

• 
• 1

  1Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• R

  RDelete

• 
• +

  +Delete

• 
• 2

  2Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• h

  hDelete

• 
• h

  hDelete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• R

  RDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout