Product Name	GSDMD
Chinese Name	Gasdermin D蛋白抗体
Alias	DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; Gasdermin-D, N-terminal; GSDMD-NT; hGSDMD-NTD; Gasdermin-D, C-terminal; GSDMD-CT; hGSDMD-CTD.
literatures	Specific References (17) | SL14287R has been referenced in 17 publications. [IF=8.469] Meng, Liping. et al. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Cell Death Dis. 2022 Jan;13(1):1-13 WB,IHC ; Rat. PubMed:35013106 [IF=5.714] Yani He. et al. Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway. INT IMMUNOPHARMACOL. 2023 Jun;119:110192 IHC,IF,WB ; Human. PubMed:37068341 [IF=5.638] Yang F et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy .(2018) Cell Death Dis.9(10):1000. WB,IHC ; Mouse. PubMed:30250027 [IF=5.055] Meng L et al. Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3. J Mol Cell Cardiol. 2019 Aug 21. pii: S0022-2828(19)30170-1. WB ; Rat. PubMed:31445005 [IF=4.932] Jindan He. et al. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. Int Immunopharmacol. 2021 Oct;99:107962 WB,IF ; Mouse. PubMed:34298396 [IF=4.858] Kun Hao. et al. Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis. Int J Biol Sci. 2020; 16(16): 3163–3173 WB ; Rat, Human. PubMed:33162822 [IF=4.379] Li, Zhifeng. et al. Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. Sci Rep-Uk. 2022 Feb;12(1):1-13 WB ; Human. PubMed:10.1038/s41598-022-06229-0 [IF=4.057] Yang F et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci 2019; 15(5):1010-1019. IF ; Mouse. PubMed:10.7150/ijbs.29680 [IF=3.943] Xiuhong Wang. et al. Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways. Int Immunopharmacol. 2021 Aug;97:107506 WB ; Mouse. PubMed:34022766 [IF=3.886] Zhaochun Liu. et al. Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. 2022 Feb 08 IHC ; Human. PubMed:35137483 [IF=3.61] Yue E et al. Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma.(2018) Phytomedicine. IF ; Human. PubMed:doi:10.1016/j.phymed.2018.09.223 [IF=3.418] Chunping Zhu. et al. Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p. 2021 Jun 06 WB ; Mouse. PubMed:34091757 [IF=3.367] Chengcheng Xiao. et al. Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling. Front Physiol. 2020; 11: 906 WB,IF ; Mouse. PubMed:32903383 [IF=3.258] Renhe Wang. et al. Identification of MicroRNA-92a-3p as an Essential Regulator of Tubular Epithelial Cell Pyroptosis by Targeting Nrf1 via HO-1. Front Genet. 2020; 11: 616947 WB,IHC ; Mouse. PubMed:33505436 [IF=3.038] Haixia Gong. et al. Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro. 2021 Feb 03 WB ; Rat. PubMed:33534059 [IF=2.945] Liu, Xin. et al. Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression. 2021 Sep 29 IF ; rat. PubMed:34586578 [IF=2.705] Yang L et al. High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis. Biochem Biophys Res Commun. 2019 Nov 25. pii: S0006-291X(19)32206-5. WB&ICF&IHC-P ; Mouse. PubMed:31780258
Research Area	Cell biology immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human(predicted:Mouse,Rat)
Applications	WB=1:500-2000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	cytoplasmic The cell membrane Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GSDMD: 31-150/484
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009] Function: Belongs to the gasdermin family. Similarity: Belongs to the gasdermin family. SWISS: P57764 Gene ID: 79792 Database links: Entrez Gene: 79792 Human SwissProt: P57764 Human Unigene: 118983 Human
Product Picture	Sample: Lane 1: Human Huvec cell lysates Lane 2: Human A431 cell lysates Lane 3: Human Hela cell lysates Primary: Anti-GSDMD (SL14287R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kDa Observed band size: 59 kDa

Cartpieces

• 
• 1

  1Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• R

  RDelete

• 
• +

  +Delete

• 
• 2

  2Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• D

  DDelete

• 
• D

  DDelete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• R

  RDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout