Product Name	CD177
Chinese Name	嗜中性粒细胞抗原CD177抗体
Alias	NB1 GP; PRV-1; HNA-2a; NB1 glycoprotein; Neutrophil Glycoprotein NB1; RGD1562941; CD177 antigen; Polycythemia rubra vera protein 1; PRV-1; NB1 glycoprotein; NB1 GP; Human neutrophil alloantigen 2a; HNA-2a; CD177; NB1; CD177_MOUSE.
literatures	Specific References (4) | SL1482R has been referenced in 4 publications. [IF=3.97] Han, Feifei, et al. "Oral administration of yeast β-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis." Journal of Functional Foods 35 (2017): 115-126. IHC-P ; Mouse. PubMed:doi:10.1016/j.jff.2017.05.036 [IF=3.73] Scott, Jason A., et al. "The Multifunctional Ca2+/Calmodulin-Dependent Kinase IIdelta (CaMKIIdelta) Regulates Arteriogenesis in a Mouse Model of Flow-Mediated Remodeling." PloS one 8.8 (2013): e71550. IHC-P ; Mouse. PubMed:23951185 [IF=3.7] Yang, Jian, et al. "Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis." Journal of Cellular and Molecular Medicine (2015). IHC-P ; Rat. PubMed:25753567 [IF=3.166] Ning YL et al. Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure. (2019) Toxicology Letters;Feb;301:90-97. IHC ; Mouse. PubMed:30423366
Research Area	immunology Cell Surface Molecule glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,Rat
Applications	WB=1:500-2000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat CD177: 521-650/818
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Highly expressed in normal bone marrow and weakly expressed in fetal liver. Expressed on neutrophils. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET). Similarity: Contains 2 UPAR/Ly6 domains. SWISS: D3ZCH9 Gene ID: 499099 Database links: Entrez Gene: 57126 Human Entrez Gene: 499099 Rat Omim: 162860 Human SwissProt: Q8N6Q3 Human Unigene: 232165 Human
Product Picture	Sample: Lane 1: Spleen (Mouse) Lysate at 40 ug Lane 2: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 3: Lymph node (Rat) Lysate at 40 ug Primary: Anti-CD177 (SL1482R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 90-120 kD Observed band size: 130 kD