RecombinantHuman Interleukin II

 

Introduction: interleukin-21 (IL-21), secreted by activated CD4+T cells, has a similar molecular structure to IL-15. It is involved in regulating B cell proliferation, and collaborates with IL-15 to promote bone marrow progenitor cell proliferation and NK cell proliferation, differentiation, and cytotoxic activity.

Aliases: rHuIL-21; Za11;  IL21

Physical properties and indexes:

Appearance: ……………… White loose body freeze-dried powder

Solubility: …………… water: 100ug/ml

Potency: ……………… 2 x 106 iu/mg

Purity: ……………… > 95%

Storage condition: -20℃, avoid light, damp, sealed and dry

Transport conditions: 2~8℃ transport

Biological activity:

Interleukin 21 (IL-21) is a pleiotropic cytokine that plays a key role in the regulation of innate and adaptive immunity as well as autoimmunity. IL-21 has a range of activities that may enhance the anti-tumor immune response. IL-21 has a single role in the treatment of melanoma. IL-21 has also shown significant activity against various types of cancer when used in combination with monoclonal antibodies or signaling inhibitors. Recombinant human interleukin 21 (rIL-21), a recombinant human interleukin, and cetuximab, a monoclonal antibody targeting epidermal growth factor receptors.

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