Cytochalasin D

 

Cytorelasin D is an effective inhibitor of actin polymerization.

Molecular formula: C30H37NO6
Molecular weight: 507.62

Alias:Cytochalasin D; Cytochalasin D Cytorelaxin D; Pinocytin D; Zygosporin A; Cytostatin C;

Physical properties and indexes:

Appearance: …………………… White crystalline powder

Solubility: ………………… Soluble in ethanol to 10 mM and in DMSO to 50 mM

Melting point: …………………… 255 ~ 260 ° C

Burning residue: ……………… < 0.1%

Purity: …………………… > 95%

Storage conditions:

-20 ℃, avoid light moisture-proof sealed dry

Biological activity

Cytorelaxin D is used in actin polymerization studies and cytological studies. Cytorelaxin is a mycotoxin characterized by a high substitution of hydrogenated isoindoles, which fuse with a large ring. They are thought to bind to the spiny ends of actin filaments, thereby inhibiting the binding and separation of subunits. Cytorelaxin D is 10 times more effective than cytorelaxin B and does not inhibit monosaccharide transport across the cell membrane. Cytorelaxin D treatment rapidly phosphorylated the tyrosine of fish (SH3PXD2A) and activated Src. Cytorelaxin D has been shown to increase intracellular Ca2+ levels and activate the p53 dependent pathway, leading to cell cycle arrest. It also acts as an inhibitor of DNA synthesis, thyroid secretion, and growth hormone release.

 

Our products are only for research purposes (non-clinical research).

 

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