Cytochalasin H

 

Molecular formula: C30H39NO5, molecular weight: 493.6

Physical properties and indexes:

Appearance: …………………… White freeze-dried powder

Solubility: ………………… Soluble in DMSO, ethanol

Burning residue: ……………… < 0.1%

Purity: …………………… > 95%

Biological activity:

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such  diverse processes as cell movement, growth, phagocytosis, degranulation,  and secretion. Cytochalasin H is a potent inhibitor of actin incorporation into filaments. Like cytochalasin D,  it also increases the steady-state diffusion coefficients of filaments,  suggesting that it stimulates filament shortening. Cytochalasin H suppresses the production of reactive oxygen species  by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes,  and shows anti-angiogenic activity bothin vitroandin vivo

Use and description: scientific research reagent.

Storage condition: -15~-20°C

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