Product Name	Recombinant Rabbit Anti-LIMK1&LIMK2 Monoclonal Antibody
Cat No.	SLA0781M
Alias	LIMK; LIMK-1; KIZ-1; LIMK1_HUMAN; LIMK1; 2.7.11.1; LIMK1_MOUSE; LIMK1_RAT; LIM domain kinase 1
Host Species	Mouse
Isotype	IgG1/Lambda
Clonality	Monoclonal
Clone No.	10E12
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human LIMK-1/2
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	72, 73 kDa
Swiss-Prot	P53667
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	LIM domain kinase 1 (LIMK1) Homo sapiens There are approximately 40 known eukaryotic LIM proteins , so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA , the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.