Product Name	Recombinant Rabbit Anti-SREBF1 Monoclonal Antibody
Cat No.	SLA0770M
Alias	HMD; IFAP2; SREBP1; bHLHd1; ADD1; ADD-1; SREBP-1; SREBP-1c; SRBP1_HUMAN; SREBF1; Class D basic helix-loop-helix protein 1 (bHLHd1); Sterol regulatory element-binding transcription factor 1; SRBP1_MOUSE; SRBP1_RAT; Adipocyte determination- and differentiation-dependent factor 1 (ADD1); sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1
Host Species	Mouse
Isotype	IgG2b/Kappa
Clonality	Monoclonal
Clone No.	5F12
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	SREBP-1 protein
Purification	Affinity-chromatography using specific immunogen.
Concentration	1mg/ml
Predicted MW.	54/126 kDa
Swiss-Prot	P36956
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1) , which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage , the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor , and the mature nuclear form is rapidly catabolized , thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq , Mar 2016]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.