Product Name	Recombinant Rabbit Anti-CK-19&CK-10 Monoclonal Antibody
Cat No.	SLA0752M
Alias	CK19; K19; K1CS; CK-19; EndoC; Krt-1.19; Krt1-19; K1C19_HUMAN; KRT19; Cytokeratin-19 (CK-19); Keratin-19 (K19); K1C19_MOUSE; keratin 19; keratin 19, type I; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament
Host Species	Mouse
Isotype	IgG1/Kappa
Clonality	Monoclonal
Clone No.	4F5
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human Cytokeratin 19
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	44 kDa
Swiss-Prot	P08727
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	CK19 is the smallest keratin with a molecular weight of 40-44 kDa. which is widely distributed in monolayer epithelial cells and many squamous epithelial tissues , and plays an important role in maintaining cell structure and morphology. Its function is related to cell proliferation , differentiation , invasion and metastasis , and cell cycle , etc. CK19 is an important biomarker of breast cancer cells , lymph nodes , peripheral blood and bone marrow tumor cells. The keratin of CK10 with molecular weight of about 60kD is not expressed in epidermal basal cells under normal conditions. When the cells generated by basal cell division undergo neoplasia , CK1 / CK10 begins to be expressed. The expression of CK10 is correlated with the differentiation degree of malignant keratinocytes , and the higher the positive expression in tissues , the stronger the differentiation represented by CK10.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.