Product Name	Recombinant Rabbit Anti-KAT7 Monoclonal Antibody
Cat No.	SLA0744M
Alias	HBO1; HBOA; MYST2; ZC2HC7; KAT7_HUMAN; KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 (MYST-2); 2.3.1.48; KAT7_MOUSE; KAT7_RAT; MYST histone acetyltransferase 2; K(lysine) acetyltransferase 7
Host Species	Mouse
Isotype	IgM/Kappa
Clonality	Monoclonal
Clone No.	2C8
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human protein.
Purification	Affinity-chromatography using specific immunogen.
Concentration	1mg/ml
Predicted MW.	71 kDa
Swiss-Prot	O95251
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. ,domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. ,domain:The N-terminus is involved in transcriptional repression , while the C-terminus mediates AR-interaction. ,function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity , a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the MYST (SAS/MOZ) family. ,similarity:Contains 1 C2HC-type zinc finger. ,subunit:Component of the HBO1 complex composed at least of ING4 or ING5 , MYTS2/HBO1 , EAF6 , and one of PHF15 , PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. ,tissue specificity:Ubiquitously expressed , with highest levels in testis.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.